Suitability of Various Filters for Sample Preparation in Dissolution Testing, Based on Drug Binding
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چکیده
Filtration is a common method of sample preparation in dissolution testing, prior to HPLC injection. The purpose of sample filtration is to remove non-dissolved solids prior to HPLC injection. Non-dissolved solids interfere with the resulting chromatography by continuing to dissolve throughout the period of the analysis and also by plugging the HPLC column. It has already been shown that sample preparation using filtration does result in more reproducible chromatography and longer column life.
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